Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol
نویسندگان
چکیده
منابع مشابه
Perillyl alcohol: applications in oncology.
Perillyl alcohol is a monoterpene isolated from the essential oils of lavendin, peppermint, spearmint, cherries, celery seeds, and several other plants. In animal studies it has been shown to regress pancreatic, mammary, and liver tumors, to exhibit possible application as a chemopreventative agent for colon, skin, and lung cancer, and as a chemotherapeutic agent for neuroblastoma, and prostate...
متن کاملProteomic analysis of endothelial progenitor cells exposed to oxidative stress.
Endothelial progenitor cells (EPCs) repair vascular damage and participate in neovascularization. Accumulating evidence has demonstrated that EPCs have therapeutic potential in reactive oxygen species (ROS)-mediated vascular diseases. In this study, to investigate the effects of oxidative stress on EPCs, EPCs were treated with H2O2 at different final concentrations for 3 h. MTT assay, scratch-w...
متن کاملPerillyl alcohol is an angiogenesis inhibitor.
Aberrant angiogenesis is essential for the progression of solid tumors and hematological malignancies. Thus, antiangiogenic therapy is one of the most promising approaches to control cancer. In the present work, we examined the ability of perillyl alcohol (POH), a dietary monoterpene with well-established tumor chemopreventive and chemotherapeutic activity, to interfere with the process of angi...
متن کاملبررسی اثرات سیتوتوکسیک هورمون تیروئیدی 4T بر سلول‌های گلایو بلاستومای مغزی (172A) در محیط کشت سلولی
Background: Studies showed thyroid hormones influence proliferation of cancer cells. The main aim of this study was to investigate the effects of cytotoxic thyroid hormone T4 on proliferation of brain glioblastoma cells (A172) in cell culture. Methods: In this laboratory experimental study, A172 cells were randomly divided into control group and groups exposed to doses 0.1, 0.5, 1, 5, 10, 20, ...
متن کاملHeat-induced apoptosis in human glioblastoma cell line A172.
OBJECTIVE Hyperthermia has been clinically applied to some types of brain tumors. However, the detailed mechanisms of this growth inhibition are not clear. The effect of mild hyperthermia on cultured human glioblastoma cell line, A172, was studied. METHODS A172 cells were heat treated (43-44.5 degrees C) for 1 hour in the growing phase. Cell viability was assessed by trypan blue dye exclusion...
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ژورنال
عنوان ژورنال: Journal of Proteomics
سال: 2010
ISSN: 1874-3919
DOI: 10.1016/j.jprot.2010.01.003